. 2011 May 5;27(1):166–173. doi: 10.1093/ndt/gfr218

Table 2.

Hazard ratios for incident stroke symptoms associated with level of eGFR^a

	Level of eGFR, mL/min/1.73m²
	≥90 (n = 9516)	60–89 (n = 9152)	45–59 (n = 1335)	<45 (n = 591)	P-trend
Any stroke symptom
Hazard ratio 1	1 (ref)	1.01 (0.93–1.11)	1.26 (1.08–1.46)	1.40 (1.15–1.70)	<0.001
Hazard ratio 2	1 (ref)	1.01 (0.92–1.11)	1.18 (1.01–1.38)	1.21 (0.99–1.48)	0.017
Symptom—sudden weakness
Hazard ratio 1	1 (ref)	1.09 (0.92–1.29)	1.49 (1.13–1.95)	1.41 (0.97–2.07)	0.004
Hazard ratio 2	1 (ref)	1.08 (0.91–1.28)	1.39 (1.06–1.84)	1.25 (0.85–1.83)	0.033
Symptom—sudden numbness
Hazard ratio 1	1 (ref)	1.03 (0.9–1.18)	1.29 (1.02–1.65)	1.45 (1.05–1.99)	0.010
Hazard ratio 2	1 (ref)	1.03 (0.9–1.19)	1.22 (0.96–1.56)	1.23 (0.89–1.71)	0.095
Symptom—sudden painless loss of vision in one or both eyes
Hazard ratio 1	1 (ref)	1.13 (0.94–1.36)	1.33 (1.00–1.78)	1.41 (0.96–2.07)	0.019
Hazard ratio 2	1 (ref)	1.16 (0.96–1.40)	1.29 (0.96–1.72)	1.24 (0.84–1.84)	0.076
Symptom—sudden loss of half vision
Hazard ratio 1	1 (ref)	1.14 (0.88–1.47)	1.22 (0.80–1.86)	1.88 (1.16–3.04)	0.025
Hazard ratio 2	1 (ref)	1.13 (0.87–1.46)	1.10 (0.72–1.69)	1.57 (0.96–2.54)	0.155
Symptom—suddenly lost ability to understand people
Hazard ratio 1	1 (ref)	0.98 (0.79–1.20)	1.44 (1.08–1.93)	1.59 (1.10–2.31)	0.002
Hazard ratio 2	1 (ref)	0.96 (0.78–1.18)	1.32 (0.98–1.78)	1.37 (0.94–2.00)	0.024
Symptom—suddenly lost ability to express self verbally or in writing
Hazard ratio 1	1 (ref)	1.03 (0.84–1.27)	1.42 (1.04–1.94)	1.58 (1.05–2.36)	0.007
Hazard ratio 2	1 (ref)	1.03 (0.83–1.27)	1.35 (0.98–1.86)	1.44 (0.96–2.18)	0.025

Ref, reference category. Numbers in table are hazard ratio (95% CI). Hazard ratio 1 is adjusted for age, race, sex and geographic region. Hazard ratio 2 is adjusted for age, race, sex, geographic region, education, household income, current smoking, alcohol consumption, BMI, systolic blood pressure, antihypertensive medication use, dyslipidemia, diabetes and elevated C-reactive protein.