Table 3.

Hazard ratios for incident stroke symptoms associated with level of albuminuria^a

	Albuminuria category, mg/g
	<10 (n = 13310)	10–29 (n = 4598)	30–299 (n = 2246)	≥300 (n = 440)	P-trend
Any stroke symptom
Hazard ratio 1	1 (ref)	1.22 (1.11–1.34)	1.43 (1.28–1.61)	1.49 (1.19–1.87)	<0.001
Hazard ratio 2	1 (ref)	1.13 (1.03–1.25)	1.25 (1.11–1.41)	1.10 (0.87–1.40)	0.002
Symptom—sudden weakness
Hazard ratio 1	1 (ref)	1.16 (0.98–1.39)	1.41 (1.14–1.74)	1.48 (1.00–2.21)	<0.001
Hazard ratio 2	1 (ref)	1.11 (0.93–1.33)	1.23 (0.99–1.53)	1.09 (0.71–1.67)	0.133
Symptom—sudden numbness
Hazard ratio 1	1 (ref)	1.25 (1.08–1.44)	1.34 (1.12–1.61)	1.26 (0.87–1.82)	<0.001
Hazard ratio 2	1 (ref)	1.17 (1.01–1.36)	1.16 (0.96–1.40)	0.92 (0.62–1.37)	0.334
Symptom—sudden painless loss of vision in one or both eyes
Hazard ratio 1	1 (ref)	1.15 (0.95–1.38)	1.55 (1.25–1.93)	1.79 (1.20–2.67)	<0.001
Hazard ratio 2	1 (ref)	1.04 (0.86–1.25)	1.31 (1.04–1.64)	1.29 (0.84–1.96)	0.029
Symptom—sudden loss of half vision
Hazard ratio 1	1 (ref)	1.30 (1.00–1.68)	1.70 (1.26–2.29)	1.51 (0.82–2.79)	<0.001
Hazard ratio 2	1 (ref)	1.13 (0.87–1.48)	1.39 (1.02–1.89)	0.95 (0.49–1.83)	0.222
Symptom—suddenly lost ability to understand people
Hazard ratio 1	1 (ref)	1.28 (1.06–1.56)	1.46 (1.15–1.86)	2.34 (1.57–3.49)	<0.001
Hazard ratio 2	1 (ref)	1.19 (0.99–1.42)	1.26 (1.01–1.58)	1.70 (1.16–2.50)	0.002
Symptom—suddenly lost ability to express self verbally or in writing
Hazard ratio 1	1 (ref)	1.25 (1.03–1.54)	1.36 (1.05–1.75)	1.35 (0.80–2.28)	0.005
Hazard ratio 2	1 (ref)	1.17 (0.94–1.46)	1.20 (0.91–1.58)	1.02 (0.57–1.82)	0.289

^aRef, reference category. Numbers in table are hazard ratio (95% CI). Hazard ratio 1 is adjusted for age, race, sex and geographic region. Hazard ratio 2 is adjusted for age, race, sex, geographic region, education, current smoking, alcohol consumption, BMI, systolic blood pressure, antihypertensive medication use, dyslipidemia, diabetes and elevated C-reactive protein.