. 2012 Mar 28;2(1):38–47. doi: 10.1159/000336817

Table 2.

Results of unadjusted and adjusted regression models for all proposed explanatory variables and the three outcomes

Variable	10-word test				TMT B				Clock Drawing Test
	unadjusted		adjusted (final model)		unadjusted		adjusted (final model)		unadjusted		adjusted (final model)

	regression coefficients (95% CI)	p value	regression coefficients (95% CI)	p value	regression coefficients (95% CI)	p value	regression coefficients (95% CI)	p value	OR estimate (95% CI)	p value	OR est imate (95% CI)	p value
WMLs	−0.30 (−0.44, −0.17)	< 0.001	−0.16 (−0.28, −0.03)	0.014	3.50 (1.83, 5.18)	< 0.001	1.75 (0.18, 3.33)	0.029	1.06 (1.02, 1.10)	0.003	1.03 (0.99, 1.07)	0.19

Age	−0.24 (−0.33, −0.14)	< 0.001			2.82 (1.80, 3.84)	< 0.001	2.09 (0.94, 3.23)	< 0.001	1.06 (1.03, 1.09)	< 0.001	1.06 (1.02, 1.10)	0.001

Sex (male = 0)	−1.17 (−3.59, 1.25)	0.34			6.12 (−21.5, 33.7)	0.66			3.59 (1.97, 6.55)	< 0.001	3.26 (1.62, 6.55)	0.001

Number of Apo E 4 alleles present	overall: p = 0.72				overall: p = 0.10				overall: p = 0.62
1 vs. 0	−0.85 (−3.80, 2.11)	0.57			−36.7 (−71.3, −2.10)	0.038			0.01 (−0.16, 0.18)	0.89
2 vs. 0	2.05 (−5.49, 9.60)	0.59			−27.3 (−114, 59.1)	0.53			0.22 (−0.22, 0.66)	0.33

MTLA (2–4 vs. 0–1)	−6.26 (−8.50, −4.02)	< 0.001	−4.51 (−6.67, −2.35)	< 0.001	70.9 (44.3, 97.5)	< 0.001	33.0 (5.86, 60.1)	0.018	3.76 (1.96, 7.22)	< 0.001

Education (≤9 years = 0)	6.55 (3.73, 9.37)	< 0.001	4.83 (2.32, 7.34)	< 0.001	−22.3 (−57.5, 12.8)	0.21			0.58 (0.29, 1.16)	0.12

Homocysteine (μmol/l)	−0.25 (−0.50, −0.009)	0.042			2.45 (−0.41, 5.32)	0.093			1.01 (0.95, 1.07)	0.82

Hypertension (treated)	−3.07 (−5.51, −0.63)	0.014			30.7 (3.52, 57.9)	0.027			1.65 (0.91, 2.99)	0.10

Hyperlipidemia	4.57 (2.22, 6.92)	< 0.001	2.72 (0.59, 4.85)	0.013	−38.3 (−65.5, −11.2)	0.006			0.82 (0.46, 1.45)	0.49

Diabetes	−3.84 (−7.63, −0.06)	0.047			63.7 (14.9, 112)	0.011	60.4 (17.2, 104)	0.006	1.61 (0.66, 3.92)	0.29

Atrial fibrillation (at present)	−1.11 (−3.80, 1.57)	0.41			17.1 (−13.0, 47.2)	0.26			1.00 (0.54, 1.88)	0.99

Coronary heart disease	−2.23 (−5.06, 0.61)	0.12			45.5 (13.7, 77.3)	0.005			0.86 (0.44, 1.71)	0.68

Cigarette smoking (at present)	−0.14 (−3.54, 3.26)	0.94			−5.65 (−45.1, 33.8)	0.78			0.83 (0.36, 1.90)	0.65

BMI	0.20 (−0.11, 0.51)	0.21			−1.47 (−5.22, 2.29)	0.44			0.91 (0.84, 0.98)	0.018

Physical activity (min/week)	0.007 (0.001, 0.01)	0.017			−0.035 (−0.10, 0.03)	0.27			0.997 (0.995, 0.999)	0.007

Diagnosis	overall: p = 0.010				overall: p = 0.53				overall: p = 0.13
TIA vs. infarction	3.63 (0.36, 6.90)	0.030			−20.7 (−57.3, 15.9)	0.27			0.40 (0.16, 0.98)	0.046
Hemorrhage vs. infarction	−3.93 (−8.17, 0.31)	0.069			0.78 (−53.4, 54.9)	0.98			0.71 (0.25, 2.03)	0.53

TOAST (small vessel disease = 0)	−2.05 (−4.67, 0.56)	0.12			30.7 (2.20, 59.2)	0.035	32.9 (7.69, 58.0)	0.011	1.15 (0.61, 2.15)	0.67

NIHSS (score on day 1)	−0.62 (−0.85, −0.38)	< 0.001	−0.28 (−0.53, −0.04)	0.017	5.33 (0.54, 10.1)	0.029	5.63 (1.02, 10.2)	0.017	1.15 (1.07, 1.23)	< 0.001	1.12 (1.04, 1.22)	0.005

Topographic location (left = 0)	3.06 (0.68, 5.44)	0.012	2.59 (0.58, 4.59)	0.009	−9.21 (−36.4, 18.0)	0.50			1.00 (0.56, 1.77)	1.00

Apo E = Apolipoprotein E; Hyperlipidemia = total cholesterol >5 mmol/l or low-density lipoprotein cholesterol >3 mmol/l; Coronary heart disease = previous myocardial infarction or present angina pectoris; BMI = body mass index. The values are the regression coefficients for the 10-word test and TMT B (linear regression) and the odds ratio for the Clock Drawing Test (logistic regression).