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. 2012 Apr 11;12:20. doi: 10.1186/1471-2377-12-20

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Copyright ©2012 Schoeler et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MEK-Inhibitor. To investigate whether the ERK1/2-pathway is involved in the mediation of dexmedetomidine's neuroprotective properties towards mechanically injured brain tissue we applied PD98059, inhibitor of ERK1/2's direct activator MEK1, in a 5 μM concentration along with 1 μM dexmedetomidine immediately after trauma. Here, n = 46 slices were subjected to the aforementioned conditions. As shown in Figure 5 trauma intensity was significantly higher in the inhibitor group than in the dexmedetomidine group (p = 0.033) but still appreciably lower than in the positive control group (p ≤ 0.001).