Table 3.
Genes showing developmental changes are enriched for genes altered by hypophysectomy
| A. Background: All genes (22,635) | Genes up regulated in male hypophysectomized liver (2,250 genes) | Genes down regulated in male hypophysectomized liver (2,202 genes) | ||||
|---|---|---|---|---|---|---|
| # of overlapping genes | Fold enrichment | Fisher Test p-value | # of overlapping genes | Fold enrichment | Fisher Test p-value | |
| All genes up regulated in male liver 3-8 wk (1,542 genes) | 213 | 1.39 | 3.05E-06 | 306 | 2.04 | 2.13E-30 |
| All genes down regulated in male liver 3-8 wk (1,773 genes) | 393 | 2.23 | 7.12E-47 | 163 | 0.95 | 0.479 |
| B. Background: All genes (22,635) | Genes up regulated in female hypophysectomized liver (1,521 genes) | Genes down regulated in female hypophysectomized liver (1,535 genes) | ||||
| # of overlapping genes | Fold enrichment | Fisher Test p-value | # of overlapping genes | Fold enrichment | Fisher Test p-value | |
| All genes up regulated in female liver 3-8 wk (1,070 genes) | 131 | 1.82 | 2.38E-10 | 151 | 2.08 | 2.91E-16 |
| All genes down regulated in female liver 3-8 wk (1,364 genes) | 203 | 2.21 | 5.87E-24 | 139 | 1.50 | 5.16E-06 |
Genes identified in the present microarray study were grouped based on their regulation from 3 wk to 8 wk and compared to genes from a previous microarray study [27] grouped by their response to hypophysectomy. Enrichments were calculated as described in Table 2. Total numbers of genes comprising each group are shown in parenthesis. Bold text indicates enrichment with a highly significant p-value (p < 0.0001, Fisher's exact test).