Table 4.

Sex-specific transcriptional regulators

Gene Name	Ihh	Klf17	Ybx2	Cdx4	Cux2	Id1	Jazf1	Tox	Trim24
Accession Number	NM_010544	NM_029416	NM_016875	NM_007674	NM_007804	NM_010495	NM_173406	NM_145711	NM_145076
Sex specificity	M	M	M	F	F	F	F	F	F
Onset of sex specificity	4 wk	8 wk	8 wk	4 wk	4 wk	8 wk	8 wk	4 wk	4 wk
Developmental change in M liver (3, 4 wk to 8 wk)	up	up	up	down	down*	down	down	down*	down
Developmental change in F liver (3, 4 wk to 8 wk)	no change	no change	up	no change	up	no change	no change	Up	up*
Response to HNF4α-knockout	down in M	down in M	-	up in M	up in M	up in M up in F	up in M up in F	up in M up in F	up in M up in F
Response to STAT5-knockout	-	-	down in M	no effect	up in M	-	no effect	up in M	up in M
Response to Hypox	down in M	down in M	-	down in F	up in M, down in F	up in M	up in M	up in M	down in F
Response to continuous GH	-	-	down in M at ≥ 4 day	up in M at ≥ 4 day	up in M at ≥ 2 day	-	no effect	no effect	up in M at ≥ 10 hr

Adult sex-specific genes with a |fold change| > 2 and p < 0.0001 for the male 8 wk vs. female 8 wk microarray comparison and having GO descriptors that contain the words "DNA binding" or "transcription" were identified as potential transcriptional regulators. The transcription factor genes listed in this table were previously found to be altered in expression in response to hypophysectomy [27], STAT5b-deficiency [32], HNF4α-deficiency [24], or treatment with continuous GH [46]. M, male, F, female

* Indicates a gene that displayed a developmental change at 4 wk but not 3 wk

- Indicates no probe for the gene on the microarray platform that was used for the analysis.