Table 4.
Analysis of polymorphisms and lung cancer risk in CAPUA study population
| MMPs | Genotype | Cases n (%) |
Controls n (%) |
ORa | [95% CI] | P | P trend |
|---|---|---|---|---|---|---|---|
| MMP9 | C/C | 581 (76.2) | 483 (74.4) | 1.00 | |||
| C/T | 174 (22.8) | 148 (22.8) | 0.96 | 0.69-1.35 | 0.830 | ||
| T/T | 7 (0.9) | 18 (2.8) | 0.23 | 0.06-0.85 | 0.027 | 0.202 | |
| MMP2 | C/C | 596 (73.0) | 465 (76.2) | 1.00 | |||
| C/T | 206 (25.2) | 125 (20.5) | 1.18 | 0.83-1.67 | 0.359 | ||
| T/T | 14 (1.7) | 20 (3.3) | 0.86 | 0.35-2.13 | 0.749 | 0.601 | |
| MMP3 | 6A/6A | 185 (25.8) | 139 (26.0) | 1.00 | |||
| 6A/5A | 367 (51.3) | 276 (51.7) | 1.19 | 0.83-1.72 | 0.339 | ||
| 5A/5A | 164 (22.9) | 119 (22.3) | 1.17 | 0.76-1.81 | 0.483 | 0.331 | |
aAdjusted by age, gender, pack-years, family history of cancer, occupation (list A), alcohol consumption (gr), and calories