Table 3.
Impact of disease and treatment on patient day-to-day limitation
| Occupation or Job | Daily activities | Lifestyle | ||||
|---|---|---|---|---|---|---|
| Group Mean (SD) | 2.11 | (1.35) | 2.25 | (1.24) | 2.45 | (1.25) |
| Adjusted R2 (N) | 0.17 | (512) | 0.17 | (512) | 0.18 | (512) |
| Age | 0.03(.04) | 0.12(.04) | ** | 0.06(.04) | ||
| AntiD aggregate bother interaction † | 0.20(.05) | **** | 0.16(.04) | *** | 0.14(.04) | ** |
| CS aggregate bother interaction † | 0.12(.04) | ** | 0.11(.04) | * | 0.09(.04) | * |
| IVIg aggregate bother interaction † | 0.21(.05) | **** | 0.15(.05) | ** | 0.17(.05) | ** |
| Rituximab aggregate bother interaction † | 0.17(.05) | *** | 0.12(.05) | * | 0.12(.05) | * |
| Splenectomy aggregate bother interaction † | 0.20(.05) | *** | 0.19(.05) | *** | 0.17(.05) | *** |
| Frequency of dry bleeds (0 = No bleeds, 1 = bleeds) | 0.05(.05) | 0.13(.05) | ** | 0.15(.05) | ** | |
| Time since last taking drug/procedure§ | 0.02(.04) | -0.04(.04) | -0.02(.04) | |||
| Gender (0 = male; 1 = female) | -0.06(.04) | -0.06(.04) | -0.05(.04) | |||
| Typical low platelet count (past year) | -0.12(.06) | * | -0.12(.06) | * | -0.11(.05) | * |
| Number of ITP treatments (among 5 treatment types) | -0.17(.07) | ** | -0.12(.07) | -0.09(.04) | ||
| Type of physician ‡ | -0.05(.04) | 0.04(.04) | 0.00(.05) | |||
| Frequency of wet bleeds (0 = No bleeds, 1 = bleeds) | 0.13(.05) | ** | 0.13(.05) | ** | 0.17(.04) | *** |
* P <0.05
* *P <0.01
* **P <0.001
* ***P <0.0001
Each model based on all patients. Patients with no side effects for a given treatment type were coded as 1.
† Interaction term = Aggregate bother (1-5) × treatment received (0,1)
‡ Type of physician referred to generalist or specialist
§ Categorical variable were 0 = Currently taking (Less than 5 years ago in case of splenectomy), 1 = Taken in the past (5 or more years ago in case of splenectomy)