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A) Notch, Wnt, TGF-β and IGF signaling act at specific times during myogenic differentiation to ensure proper differentiation. B) Our data predicts that activation of Notch and IGF-1 signaling pathways and attenuation of Wnt and TGF-β signaling pathways will lead to impaired differentiation by maintaining the progenitors in a proliferative state and exhausting the satellite cell niche.
