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. 2012 May 11;7(5):e36336. doi: 10.1371/journal.pone.0036336

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Bidan et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Quantitative analysis of tissue growth in circular pores (CIR) and on semi-circular channels (SC) of 1 mm diameter. A - The average curvature along the perimeter of the circular pore and on a given portion of the semi-circular surfaces is measured on experimental images at different culture times. As theoretically circular pores should be filled in about 432 steps or 25.4 days. B - The projected tissue area (PTA) is normalised by the area of the pore (PA) at D4 (reference) and reported as a function of culture time. In A and B, the full lines correspond to the prediction given by CCTG (; ). A lag time is used to overlap simulated and experimental data ( and ). C - Growth rates are calculated between D7 and D14 with the experimental and the simulated data as well as data simulated on ideal geometries with a radius derived from the experimental images. ANOVA analysis shows no significant differences between the methods used but a statistical difference in the tissue growth rates achieved in CIR and SC (). Dots and error bars represent mean values and standard errors, respectively ().

Inline graphic — Quantitative analysis of tissue growth in circular pores (CIR) and on semi-circular channels (SC) of 1 mm diameter. A - The average curvature along the perimeter of the circular pore and on a given portion of the semi-circular surfaces is measured on experimental images at different culture times. As theoretically circular pores should be filled in about 432 steps or 25.4 days. B - The projected tissue area (PTA) is normalised by the area of the pore (PA) at D4 (reference) and reported as a function of culture time. In A and B, the full lines correspond to the prediction given by CCTG (; ). A lag time is used to overlap simulated and experimental data ( and ). C - Growth rates are calculated between D7 and D14 with the experimental and the simulated data as well as data simulated on ideal geometries with a radius derived from the experimental images. ANOVA analysis shows no significant differences between the methods used but a statistical difference in the tissue growth rates achieved in CIR and SC (). Dots and error bars represent mean values and standard errors, respectively ().