Table 1.
Test Scores and Plaque and Tangle Loads
| Measure | Total Sample Mean (SD) |
NC Mean (SD) |
MCI Mean (SD) |
|---|---|---|---|
| Memory Functioning Questionnaire Factors* | |||
| Frequency of forgetting (MFQ1)** | 159 (24) | 168 (24) | 151 (24) |
| Seriousness of forgetting (MFQ2) | 81 (22) | 82 (22) | 80 (21) |
| Retrospective functioning (MFQ3) | 13 (4) | 13 (4) | 14 (5) |
| Mnemonics use (MFQ4) | 22 (9) | 21 (7) | 23 (10) |
| FDDNP-PET Cortical Binding Levels*** | |||
| Global | 1.10 (0.03) | 1.08 (0.02) | 1.11 (0.03) |
| Medial Temporal Lobe | 1.13 (0.04) | 1.11 (0.04) | 1.15 (0.03) |
| Lateral Temporal Lobe | 1.10 (0.05) | 1.08 (0.04) | 1.12 (0.04) |
| Parietal Lobe | 1.08 (0.03) | 1.07 (0.03) | 1.09 (0.03) |
| Posterior Cingulate Gyrus | 1.12 (0.04) | 1.12 (0.03) | 1.12 (0.04) |
| Frontal Lobe | 1.06 (0.04) | 1.05 (0.03) | 1.06 (0.04) |
Figures indicate mean with standard deviation (SD).
Abbreviations: FDDNP-PET = 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile positron emission tomography; MCI = Mild Cognitive Impairment; NC = Normal Control
For the Memory Functioning Questionnaire, higher scores indicate fewer self-reported memory problems and less use of mnemonics. Norms for people age 60–69 years and 70–79: frequency of forgetting = 152 (28) and 149 (29); seriousness of forgetting = 86 (20) and 84 (21); retrospective functioning = 18 (6) and 18 (6); and mnemonics usage = 31 (9) and 30 (10).
MFQ1 mean values significantly different for NC and MCI groups: t(48) = 2.5, p =.02.
FDDNP-PET cortical binding levels different for NC and MCI groups. Global: t(55) = 3.7, p = .0005; medial temporal lobe: t(55) = 4.4, p < .0001; lateral temporal lobe: t(55) = 3.1, p = .0004; parietal: t(55) = 3.1, p = .003.