Table III. “Inducible” GAPDH Functions.
Function | Activity | Reaction | Initial Subcellular Localization | Final Subcellular Localization |
---|---|---|---|---|
Receptor Mediated Cell Signaling | Regulation of gene expression | Androgen Receptor Transactivation | Cytosolic | Nuclear |
Chromosomal Replication | Histone Biosynthesis | Formation of Oct-1 OCA-S coactivator protein complex | Cytosolic | Nuclear |
Apoptosis | Nuclear Protein Degradation; regulation of apoptotic gene expression | Binding to and stabilization of Siah1; induction of P300/CBP; Transnitrosylation | Cytosolic | Nuclear |
Autophagy | Regulation of Gene Expression | Induction of Agt12 | Cytosolic | Nuclear |