Table 1.

Differentially regulated gene transcripts following 4 and 24 h differentiation of C2C12 cells in SM with 500 μM GTP

Gene symbola	Description	IGTP/ICtrl 4 h of differentiationb	IGTP/ICtrl 24 h of differentiationb
Cytoskeleton structure
Macs	Myristoylated alanine-rich protein kinase c substrate		4.7
Sgcb	Sarcoglycan, beta (dystrophin-associated glycoprotein)		2.1
Respiratory chain
ND1	Nadh dehydrogenase subunit 1	2.3
Cox7b	Cytochrome c oxidase subunit VIIb	2
Cox7a1	Cytochrome c oxidase subunit VIIa 1		2
Protein balance
Ubc	Ubiquitin c	0.5
Ubqln2	Ubiquilin 2		0.13
Energetic metabolism
Cpt2	Carnitine palmitoyltransferase 2		42.6
Acatn	Acetyl-coenzyme a transporter		28
Gapdh	Glyceraldehyde-3-phosphate dehydrogenase	2
Myogenesis
Ndn	Necdin	2.7
Pax7	Paired box transcription factor pax7	2.5
Myod1	Myogenic differentiation 1		1.4
Rab17	Rab17, member ras oncogene family		2
Gsk3b	Glycogen synthase kinase 3 beta		2.2
Ppp3ca	Calcineurin	1.1	1.2
Cell adhesion
Catna1	Catenin alpha 1		0.46
Vcam1	Vascular cell adhesion molecule 1	1.7	0.9
Ncam-180	Neuronal cell adhesion molecule ncam-180	1.5	2.4
–	Homologue to metastasis-associated gpi-anchored protein	0.5
Mrc2	Mannose receptor, c type 2	0.4	0.46
Others
Saa3	Serum amyloid a 3	2.5	5.5
Hoxc4	Homeo box c4	0.5

^aGene symbols as described in the NCBI database

^bChanges in gene expression levels as log base-2 of the ratios (log₂ I_GTP-treated/I_non-treated): >2, up-regulated genes; <0.5, down-regulated genes