Fig. 2.

P2Y₁ receptors mediate the ATP-evoked increase in synaptic input in mitral cells. a Repetitive photorelease of ADP by photolysis of NPE-ADP (100 μM) evokes inward currents in mitral cells. b The difference between ADP-evoked inward currents and ATP-evoked inward currents was statistically not significant (n.s.). c Effects of the P2 receptor antagonist PPADS and (d) the P2Y₁-specific antagonist MRS 2179 on ATP-evoked inward currents. e ATP-evoked currents were significantly reduced by PPADS and MRS 2179. f Membrane current in a mitral cell (upper trace) and calcium transients in Fluo-4-loaded astrocytes (lower traces, five individual cells are shown as examples) evoked by photolysis of caged ATP. g Traces as shown in F at expanded time scale. The current response in the mitral cell precedes the calcium responses in astrocytes