Fig. 3.

The increase in synaptic input in mitral cells evoked by photolysis of caged ATP includes glutamatergic and GABAergic postsynaptic currents. a Effect of suppressing action potentials with TTX on ATP-evoked synaptic activity measured in a mitral cell. b Effect of inhibition of GABAergic transmission by gabazine, and c inhibition of glutamatergic transmission by NBQX/D-AP5 on ATP-induced synaptic input in mitral cells. d Statistical evaluation of the effects of TTX (1–2 μM), gabazine (10 μM), and combined application of 10 μM NBQX and 50 μM D-AP5 on synaptic currents evoked by the first and second photolysis of caged ATP. All three drugs significantly reduced the current integral as compared to the control current recorded in the absence of antagonists. ***, p < 0.005