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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: J Struct Biol. 2012 Jan 10;178(2):165–176. doi: 10.1016/j.jsb.2012.01.004

FIGURE 9.

FIGURE 9

Effect of eliminating sub-volumes with lower SNRs on conformational separation. (a-d) Two-dimensional histograms of the projection of the scatter-clouds of the reduced dimensionality representation showing smallest overlap. The histograms in panels (a,c) are for the SIVmac239/SIV CP-MAC mixture and in panels (b,d) for SIVmac239/SIV CP-MAC+sCD4+7D3 mixture. In panels (a-b), only the third of the data set with highest quality was incorporated in the iterative classification and alignment. The overlaps between the histograms in panels a and b are ~25% and 2% respectively. In panels (c-d), the iterative classification and alignment was performed using all the data but only the third of the data set with highest quality was depicted in the histogram. The overlaps between the histograms in panels c and d are ~50% and 43% respectively. Contour lines related to the SIVmac239 sample are colored red. Contour lines related to the SIV CP-MAC and SIV CP-MAC+sCD4+7D3 samples are colored blue. The overlap between the histograms of the SIVmac239 and SIV CP-MAC sub-volumes is ~8%.