Fig. 5.

Estrogen receptor ligand treatment of mice with EAE inhibits Purkinje cell loss. A graph of the number of calbindin-2⁺ cells in the cerebella of ovarectomized vehicle-treated healthy controls (CON), ovarectomized vehicle-treated EAE mice (EAE), ovarectomized E2-treated EAE mice (E2), ovarectomized ER-alpha ligand-treated EAE mice (ERa) and ovarectomized ER-beta ligand-treated EAE mice (ERb). Error bars indicate SEM. Asterisks indicate statistical significance (* p < 0.01, ** p < 0.001, *** p < 0.0001, **** p > 0.00001). All significant differences survive the application of the Bonferroni correction for post hoc testing.