Fig. 1.

Physiological effects of aldosterone with losartan. Adrenalectomized rats received no aldosterone (Control, n = 5), normal aldosterone (Aldo, n = 5), or high aldosterone (Aldo-H, n = 5) with losartan for 8 days. At the end of the experiment, the plasma renin activity and the plasma aldosterone concentration were measured (a, b). During the experiment, arterial blood pressure and 24-h urinary sodium excretions were measured (c, d). By analysis of variance and post hoc test. MAP mean arterial pressure, NS not significant; *P < 0.01