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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Prostaglandins Other Lipid Mediat. 2012 Apr 2;98(0):23–30. doi: 10.1016/j.prostaglandins.2012.03.002

Fig. 1. Improved survival and enhanced bacterial containment after pneumococcal infection in mice lacking the EP2 receptor.

Fig. 1

Female wild type (WT) C57BL/6 or EP2 receptor knockout (EP2 KO) mice were infected intratracheally (A) with S. pneumoniae as detailed in the Materials and Methods section. Survival was monitored for 10 days. The number of mice per group is shown. *P < 0.05 by Mantel-Cox log-rank test. (B) Bacterial loads (CFU S. pneumoniae per gram of homogenized tissue) in the lung and spleen of WT and EP2 KO mice 24 h after infection (n = 5 mice per experimental group). *P < 0.05 by Student t-test; n.s., not significant. Data from one representative experiment of two independent experiments yielding similar results are shown.