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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Prostaglandins Other Lipid Mediat. 2012 Apr 2;98(0):23–30. doi: 10.1016/j.prostaglandins.2012.03.002

Fig. 2. Enhanced acute inflammation in EP2 receptor deficient mice after S. pneumoniae lung infection.

Fig. 2

(A) Bronchoalveolar lavage fluid (BALF) cell counts were determined in wild type (WT) and EP2 knockout (KO) mice as detailed in the Materials and Methods section 24 h after intratracheal inoculation with S. pneumoniae. *P < 0.05 by Student t-test (n = 5 mice per group). (B) Pulmonary inflammation was quantitated using a summary severity score calculated through blinded histopathological analysis as described in the Materials and Methods section. EP2 KO mice demonstrated a trend towards more severe acute inflammation in the lungs 24 hr after infection. *P = 0.099 by Student t-test. Data from one representative experiment of two independent experiments yielding similar results are shown