Table 2.

Type and frequency of mutations described in the pncA promoter region and the region between residues 132 and 142 of the PncA^a

Mutation site	Nucleotide change	Amino acid change		Frequency
-16∼-11	AACGTA to GGCAGTT	Mutation in promoter		1
-12	T to G	Mutation in promoter		1
-11	A to C	Mutation in promoter		1
-11	A to G	Mutation in promoter		13
-7	T to C	Mutation in promoter		1
394	G to A	Gly132	Ser	2
395	G to A or T	Gly132	Asp or Val	4
398	T to C	Ile133	Thr	1
401	C to T	Ala134	Val	3
403	A to C	Thr135	Pro	2
406	G to C	Asp136	His	1
407	A to G	Asp136	Gly	1
410	A to C or G	His137	Pro or Arg	4
413	G to A or C	Cys138	Thr or Ser	5
415	G to C or A	Val139	Leu or Met	5
416	T to C or G	Val139	Ala or Gly	6
421	C to T	Gln141	termination	1
422	A to C	Gln141	Pro	3
424	A to C or G	Thr142	Pro or Ala	2
425	C to A or T	Thr142	Lys or Met	8
402∼403	CC insertion	Frameshift		1
407∼408	C insertion	Frameshift		1
416∼417	TG deletion	Frameshift		1
395∼411	17-bp deletion	Frameshift		1

^a The mutations described here were cited from references [4, 5, 9, 11,12,13,14, 16] and the present study