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Contributions of talin-1 to cell–ECM rigidity-sensing, as determined by atomic force microscopy (AFM) cortical stiffness measurements of siCTL cells (grey squares) and siTLN1 cells (black circles) cultured on defined-rigidity substrates 3 days after the corresponding siRNA treatment. Talin-1 suppression led to modest but statistically significant cell stiffening on the softest (2 kPa) substrates. On the stiffest substrates, no differences were observed.
