Table 2.

Relationship between cell stiffness, junctional permeability and aqueous humour outflow resistance. Red arrows are measurements made on outflow pathway cells/tissues; blue arrows are measurements on vascular endothelial cells; black arrows are measurement on other cell types. Dash indicates no effect.

agent	outflow resistancea	stiffness	junctional resistanceb	reference
colchicine	↓	↓	?	[47–49]
cytochalasin D	↓	↓	↓	[31,47,50–53]
dibutyryl-cAMP	↓	↓d	↑	[17–19,32,50,54]
forskolin	↓−	↓	↑↓	[19,32,54–57]
isoproterenol	↓−	↓d	↑↓	[17,20–23,32,50,57]
latrunculin	↓	↓d	?	[15,31,58]
Y-27632	↓	↓d	↓	[14,16,31]
butanedione monoxime	↓	↓	?	[59,60]
bradykinin	↑	↑	↓	[32,61–63]
histamine	↑	↑	↓	[32,52,61,63]
thrombin	↑	↑d	↓	[14,54,61,64,65]
lysophosphatidic acid	↑	↑d	↑↓	[13,52,66–68]
sphingosine 1-phosphate	↑	↑d	↑	[12,13,69,70]
dexamethasone	↑	↑	↑	[71–74]
triamcinolone acetonide	↑	↑	↑c	[71,75,76]

^aOutflow resistance is the inverse of outflow facility.

^bJunctional resistance as determined from electrical resistance, hydraulic conductivity or permeability to solutes.

^cResponse to corticosteroid.

^dMeasurements on SC cells from this study.