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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Dev Neurobiol. 2012 Jun 21;72(9):1196–1212. doi: 10.1002/dneu.20985

Figure 2. Neurogenesis occurs normally in Kif3acko cortices.

Figure 2

(A–D) Immunostaining of E11.5 coronal sections of Kif3ahet (A and C) and Kif3acko (B and D) brains. Calretinin labels Cajal Retzius cells and TuJ1 is a pan-neuronal marker. (E) Quit fraction analysis of E12.5 cortices. About 7% more neurons are produced in Kif3acko than Kif3ahet cortices in a 24-hour period. (F–I) Immunostaining of E13.5 coronal sections of Kif3ahet (F and H) and Kif3acko (G and I) brains. Tbr1 labels preplate and layer 6 neurons. (K–N) In situ hybridizations of E18.5 coronal sections showing that fate specification is normal in Kif3acko brains. Kitl marks deep-layer neurons and Cux2 labels superficial neurons.