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. Author manuscript; available in PMC: 2012 May 13.
Published in final edited form as: Immunol Res. 2011 Apr;49(1-3):192–201. doi: 10.1007/s12026-010-8181-y

Figure 2. Regulation of Jα chromatin accessibility.

Figure 2

Wild-type and genetically manipulated versions of the Jα array are depicted. ΔTEA and ΔTEAΔJ49 carry deletions of the TEA and J49 promoters. TEA-T and 56R carry insertions of a transcription terminator downstream of TEA or Jα56, respectively. HYα carries an insertion of a TRAV17-Jα57 rearrangement. Large arrows identify major promoters (TEA, J49). Small arrows identify minor or cryptic promoter activity. Shaded portions of the ΔTEA,ΔTEAΔJ49, TEA-T and 56R alleles identify areas of diminished chromatin modifications and disrupted Vα-to-Jα recombination.