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. 2012 Apr 30;2012:980941. doi: 10.1155/2012/980941

Table 1.

Examples of in vitro models to study Parkinson's disease derived from patient iPSC.

Gene Genetic disease Genetic alteration References
SNCA Autosomal dominant Triplication of α-synuclein locus [31]
G209A mutation [43]
LRRK2 Autosomal dominant p.G2019S mutation [30]
PINK1 Autosomal recessive p.Q456X and p.V170G mutation [45]
Idiopathic condition Idiopathic [32, 42]