(a) TSC. Definite TSC: two major or one major and two minor features; probable; TSC: one major and one minor feature; possible TSC: one major or two or more minor features

Major features	Minor features
Cortical tubers	Dental enamel pits
Subependymal nodules	Hamartomatous rectal polyps
Subependymal giant cell astrocytoma	Bone cysts
Hypomelanotic macules (3 or more)	Cerebral white matter radial migration lines
Shagreen patch	Gingival fibromas
Facial angiofibromas or forehead plaque	Nonrenal hamartoma
Multiple renal nodular hamartomas	Retinal achromatic patches
Nontraumatic ungual or periungual fibromas	“Confetti” skin lesions
Cardiac rhabdomyoma	Multiple renal cysts
Pulmonary lymphangiomyomatosis and/or renal angiomyolipomas