(d) PTHS (Only Cowden syndrome has diagnostic criteria). Cowden syndrome. Operational diagnosis: mucocutaneous lesion alone if: 6 or more facial papules, 3 or more trichilemmoma; cutaneous facial papules and oral mucosal papillomatosis; oral mucosal papillomatosis and acral keratosis, or 6 or more palmoplantar keratosis; or two or major criteria, including macrocephaly or adult Lhermitte-Duclos disease; or one major or three minor criteria; or four minor criteria

Pathognomic criteria	Major criteria	Minor criteria
Adult Lhermitte-Duclos	Breast cancer	Intellectual disability
Mucocutaneous lesions	Thyroid cancer	Other thyroid lesions
	Macrocephaly	GI hamartomas
	Endometrial cancer	Fibrocystic breast disease
		Lipomas; fibromas
		Genitourinary tumors or malformations

EIF4E (No diagnostic criteria).