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. 2012 Apr 1;11(7):1364–1373. doi: 10.4161/cc.19765

Figure 6.

Figure 6

DCS treatment of KG-1a cells with innate resistance to 1,25D also reduces the expression of HPK1-C fragments and increases differentiation. (A) CD11b and CD14 expression in KG-1a cells treated by 1 nM 1,25D or DCS (with 1 nM 1,25D) for 72 h. A typical FC image of CD11b (treated for only 48 h) is shown above the summary bar-graph. The left-side peaks overlap and show the negative cell population. The one right-side peak resulting from DCS exposure is apparent. (B) Real-time RT-PCR for HPK1 mRNA in 1,25D or DCS-treated KG-1a cells relative to 18S rRNA as control. There was no significance (p > 0.05) of the mRNA level between control group and 1,25D/DCS group. (C) Western blots of HPK1-JNK-AP-1 signaling pathway in KG-1a cells.