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Nutlin-3 disrupts KSHV latency by inducing viral lytic gene expression. (A) KSHV lytic transcripts RTA (ORF50), ORF-K2, ORF-K1, ORF59, ORF65 and ORF-K8.1 and latent transcript vFLIP (ORF71) from TIVE-KSHV cells at 72 hpt with Nutlin-3 or placebo were measured by real-time PCR; (B) IFA staining of KSHV small capsid protein ORF65 with an anti-ORF65 monoclonal antibody on TIVE-KSHV cells at 96 hpt with Nutlin-3 or placebo. DAPI staining was used to reveal all cells in the fields.
