Effect of eplerenone and apocynin on systolic blood pressure and urinary 8-isoprostane levels. Figure 1A represents the systolic blood pressure after 4 weeks on either a low-salt (LS) or a high-salt (HS) diet, with or without (control) treatment with aldosterone in the presence of eplerenone or apocynin. Figure 1B shows urinary 8-isoprostane levels following 4 weeks on the treatment protocols.
Data are represented as mean ± SEM for six animals per group. Significant difference (p < 0.05) from the LS group’s systolic blood pressure is denoted by #; * denotes significant difference (p < 0.05) from the control group (no drug treatment: low and high salt); ** denotes significant difference (p < 0.05) from aldosterone treatment only.