Table 2.
Univariate and multivariate analysis for complete response and overall survival.
| Complete response | Overall survival | |||
|---|---|---|---|---|
| Variable | Univariate OR (95% CI)# | Multivariate OR (95% CI)# | Univariate HR (95% CI)# | Multivariate HR (95% CI)# |
| Age: ≥60 years | 1.34 (0.52, 3.45) | Not tested | 1.31 (0.68, 2.54) | Not tested |
| Sex: female | 0.94 (0.37, 2.39) | Not tested | 1.21 (0.62, 2.33) | Not tested |
| B symptoms | 10.29 (3.05, 34.71)*** | 10.6 (1.79, 62.65)** | 3.20 (1.53, 6.71)** | Not tested |
| Bulky diseases | 2.95 (1.1, 7.88)* | 5.32 (1, 28.23)* | 0.84 (0.42, 1.68) | Not tested |
| Stage: III-IV | 2.1 (0.77, 5.73) | Not in final model | 1.94 (0.93, 4.05) | Not in final model |
| BM involvement | 1.89 (0.69, 5.2) | Not in final model | 1.54 (0.79, 3.0) | 0.30 (0.11, 0.82)* |
| Liver involvement | 1.27 (0.41, 3.91) | Not tested | 1.50 (0.74, 3.01) | Not in final model |
| Extranodal involvement: >2 | 2.09 (0.57, 7.6) | Not in final model | 2.47 (1.19, 5.14)* | 2.60 (1.03, 6.51)* |
| Performance status: ECOG 2–4 | 6.3 (1.54, 25.83)* | Not in final model | 4.37 (2.12, 8.98)*** | 4.44 (1.84, 10.72)*** |
| High serum LDH | 3.43 (1.22, 9.67)* | Not in final model | 3.85 (1.67, 8.89)** | 1.53 (0.53, 4.46) |
| IHC: T-cell | 4.45 (1.05, 18.94)* | Not in final model | 2.22 (0.92, 5.36) | Not in final model |
| Anemia | 6.31 (2.14, 18.63)*** | 10.9 (1.63, 73)** | 3.92 (1.83, 8.42)*** | 4.14 (1.40, 12.26)* |
| Lymphopenia | 2.18 (0.8, 5.96) | Not in final model | 1.80 (0.90, 3.57) | 2.25 (1.00, 5.07)* |
| IPI: HI-high | 1.94 (0.53, 7.13) | Not in final model | 3.24 (1.60, 6.53)** | Not tested |
| Chemotherapy: | ||||
| CHOP | 0.25 (0.05, 1.4)* | 0.2 (0.02, 2.42)*** | 0.41 (0.18, 0.90)* | 0.13 (0.04, 0.41)*** |
| R-CHOP | 0.07 (0.01, 0.51) | 0.01 (0, 0.26) | 0.24 (0.09, 0.64)** | 0.04 (0.01, 0.19)*** |
| Serum VEGF (pg/mL) | ||||
| >668.0 (mean) | 2 (0.75, 5.3) | 5.33 (0.97, 29.27)* | 1.37 (0.71, 2.64) | Not in final model |
| >516.0 (median) | 2.12 (0.82, 5.49) | Not tested | 0.99 (0.51, 1.90) | Not tested |
| >835.5 (3rd Qu) | 1.76 (0.58, 5.38) | Not tested | 1.03 (0.48, 2.18) | Not tested |
| Serum bFGF (pg/mL) | ||||
| >12.15 (mean) | 1.19 (0.44, 3.23) | 1.68 (0.37, 7.71) | 2.08 (1.07, 4.03)* | 3.31 (1.32, 8.30)* |
| >9.85 (median) | 1.86 (0.69, 4.98) | Not tested | 1.75 (0.90, 3.42) | Not tested |
| >17.60 (3rd Qu) | 1.24 (0.4, 3.87) | Not tested | 1.96 (0.97, 3.94) | Not tested |
#Significance level: ***0.001, **0.01, *0.05.