Table 2. Changes in the clinical data after PDT in the two treatment groups.
|
Day 4 |
Month 1 |
Month 3 |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Half-dose PDT group | P value | One-third-dose PDT group | Half-dose PDT group | P value | One-third-dose PDT group | Half-dose PDT group | P value | One-third-dose PDT group | |
| Mean±SEM gained BCVA (ETDRS letters) | 0.4±0.7 | NS | 0.0±0.9 | 2.7±1.6 | NS | 1.7±1.7 | 5.4±1.0 | NS | 1.7±2.2 |
| (Mean±SEM BCVA) (ETDRS letters) | (76.4±2.9) | (72.7±4.0) | (78.7±2.5) | (74.3±4.0) | (81.4±3.0) | (74.3±4.4) | |||
| Mean±SEM gained retinal sensitivity (dB) | 0.3±0.4 | NS | 0.9±0.3 | 2.4±0.3 | 0.011 | 0.8±0.5 | 3.4±0.6 | 0.030 | 0.9±0.8 |
| (Mean±SEM retinal sensitivity) (dB) | (15.1±0.7) | (15.9±0.8) | (17.2±0.5) | (15.8±1.2) | (18.1±0.3) | (15.9±1.4) | |||
| Mean±SEM relative choroidal thickness (%) | 96.8±1.9 | NS | 98.1±2.8 | 83.3±2.9 | 0.023 | 97.3±3.7 | 83.5±2.8 | 0.013 | 98.0±3.0 |
| (Mean±SEM choroidal thickness) (μm) inside the PDT-applied area | (374±23) | (345±20) | (324±25) | (343±25) | (325±25) | (345±22) | |||
| Mean±SEM relative choroidal thickness (%) | 97.9±1.3 | NS | 99.5±0.6 | 87.2±2.4 | 0.013 | 98.9±3.1 | 86.1±1.4 | 0.001 | 97.5±1.9 |
| (Mean±SEM choroidal thickness) (μm) outside the PDT-applied area | (284±22) | (252±31) | (253±20) | (252±34) | (249±19) | (248±33) | |||
| Mean±SEM relative size of the choroidal vein (%) | 84.8±3.0 | 0.039 | 95.8±2.8 | 70.5±3.5 | 0.003 | 93.3±3.8 | 69.0±4.6 | 0.001 | 97.0±2.3 |
| (Mean±SEM size of the choroidal vein) ( × 103μm2) inside PDT Applied Area | (64.3±11.9) | (69.2±12.3) | (52.1±8.6) | (67.7±12.4) | (50.4±9.0) | (69.7±12.2) | |||
| Mean±SEM relative size of the choroidal vein (%) | 91.2±1.8 | 0.030 | 98.2±1.5 | 80.6±2.4 | 0.002 | 97.6±2.9 | 80.0±2.2 | 0.001 | 98.9±2.2 |
| (Mean±SEM size of the choroidal vein) ( × 103μm2) outside the PDT-applied area | (60.0±6.6) | (61.3±6.8) | (53.3±6.8) | (61.0±7.1) | (52.7±6.5) | (61.5±6.4) | |||
Abbreviations: BCVA, best-corrected visual acuity; ETDRS, Early Treatment of Diabetic Retinopathy Study; SEM, standard error of the mean; PDT, photodynamic therapy; NS, not statistically significant.
Relative choroidal thickness and relative size of the choroidal vein show the percentage change of choroidal thickness and size of the choroidal vein after PDT compared with baseline. Comparisons between the two treatment groups were made using Mann–Whitney U test. P values <0.05 were considered to be statistically significant.