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. 2010 Mar 20;401(2):228–235. doi: 10.1016/j.virol.2010.02.029

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Fig. 3 — KZ52 inhibits cathepsin L-activation of fusogenic GP. (A) CatL cleavage of virion-associated GP in the presence of boiled (Control) or native KZ52 as assessed over time by immunoblotting using control JCB antibody reagent. Indicated are full length GP1 (GP_CatL0), CatL-cleaved intermediate fragment (GP_CatL1), and CatL-cleaved fusogenic GP (GP_CatL2). (B) Mean luminosity of immunoblot data for boiled KZ52 (Control; open circles) and native KZ52 (closed circles). (C) Densitometry of immunoblot data for CatL cleavage in the presence of J3PK11 (triangles), 13C6 (squares), 6D3 (diamonds), and control, non-neutralizing, MUC-binding mAb 13F6 (stars) over time and expressed as mean luminosity. Data are from the same gel and experiments were performed at least twice with similar results.