Fig. 4.

Recognition of fusogenic GP by JP3K11 blocks EBOV entry. (A) CatL-treated (CatL-GP) viral pseudotypes were incubated with various concentrations of 6D8, 6D3, 13C6, KZ52, and JP3K11 for 1 h prior to infection of HUVEC cells and luciferase activity was measured 72 h later. Data is displayed as % infection relative to infection in the absence of antibody. (B) Neutralization of (black bars) WT (Native GP) and (white bars) CatL-GP pseudoviruses by KZ52, JP3K11, and a Control, 6D8. The experiments were performed three times independently and error bars represent ± SEM.