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. Author manuscript; available in PMC: 2013 Apr 27.
Published in final edited form as: Cell. 2012 Apr 27;149(3):515–524. doi: 10.1016/j.cell.2012.04.005

Figure 1.

Figure 1

Anticorrelated expression of miRNAs and targets in developmental transitions. In the Drosophila embryo, neurectodermal progenitors express miR-124 as they differentiate into neurons. Neuronal genes that are induced during this transition tend not to have miR-124 sites, whereas genes expressed in epidermal tissues that are also ectodermal derivatives are enriched for miR-124 sites (Stark et al., 2005). Thus, expression of miR-124 stabilizes the neuronal transition. A reciprocal pattern holds for the ectoderm-specific miR-9a.