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. Author manuscript; available in PMC: 2012 May 14.
Published in final edited form as: Cerebellum. 2009 Jul 11;8(3):231–244. doi: 10.1007/s12311-009-0125-5

Fig. 7.

Fig. 7

a, b Double immunofluorescence showing CaB (red, a) and inositol monophosphatase 1 (green, b) immunostaining in PCs in a 4-week-old SCA1 mouse. c Merged image. Arrows indicate PC vacuoles containing IMPA1. d–f Co-localization of IMPA1 (green, d) and S100B (red, e) in a 10-week-old SCA1 homozygous mouse. At 10 weeks, the PC layer is disorganized. Small arrow in e shows S100B-positive BG. Big arrows in e and f show a large vacuole in PC. f Merged image. Bar=10 μm. g, h Human cerebellar sections showing IMPA1 (green) and S100B (red) immunostaining. IMPA1-positive PC in a normal control patient (g) does not show any vacuole. In contrast, S100B and IMPA1-immunostained cytoplasmic vacuole (arrow) is visible in the surviving PC of SCA1 patient (h). Bars=10 μm