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. 2012 Jan 11;40(9):4193–4202. doi: 10.1093/nar/gkr1284

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Model of SATB1-mediated transcriptional regulation. (A) Schematic showing SATB1 assembles into a tetramer by oligomerization of its N-terminal ULD domain. (B and C) Schematic representation of a possible model for SATB1 oligomer-mediated transcriptional regulation. The SATB1 dimer or tetramer may regulate gene expression by recognizing specific DNA sequences in the promoter regions of various genes (B), and the SATB1 tetramer may organize higher-order chromatin architecture to coordinately regulate gene expression over long distances by anchoring specialized DNA sequences in close proximity and recruiting various chromatin remodeling factors (bottom).