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In vitro potency of single strands compared to duplex siRNAs. (A) ApoB (8786) and (B) ApoB (6981) compared as 2′OH and 2′F guide strands with 5′ phosphorylation. Single strands are ∼20- to 80-fold less potent than the corresponding duplex siRNAs containing identical guide strands. Potency and mRNA knockdown values listed in Supplementary Table S1.
