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. 2012 Jan 16;40(9):4125–4136. doi: 10.1093/nar/gkr1301

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — In vivo knockdown of single strand versus duplex siRNA demonstrates ssRNAi activity in vivo. RNAs formulated in a lipid nanoparticle (LNP) delivery vehicle. Modified guide strands (2'F) are compared to unmodified (2'OH). All oligos contain 5' phosphorylation. Comparison of Day 3 ApoB mRNA knockdown after an LNP delivered 3 mg/kg dose of dsRNA or ssRNA for target sites (A) ApoB (8786) and (B) ApoB (6981). Knockdown of 60–75% was observed for phosphorylated single strands containing 2'F modifications. Duration of mRNA knockdown after an LNP delivered 6 mg/kg dose was measured over 2 weeks (Day 2, Day 7, Day 14 time points) for (C) ApoB (8786) and (D) ApoB (6981). Knockdown values shown in Supplementary Table S2.