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. 2012 Jan 16;40(9):4125–4136. doi: 10.1093/nar/gkr1301

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Inclusion of three abasic residues at positions 1–3 (3aba) of the guide strand decreases the in vitro mRNA knockdown of both duplex and single strands of ApoB siRNAs. Ribose (2'OH, ‘r’) and fluoro (2'F, ‘f’) oligos with phosphate (5'p) are compared to those containing 3aba for (A) ApoB (8786) and (B) ApoB (6981). Abasic (3aba) data for additional ApoB and SSB siRNAs are shown in Supplementary Figure S3.