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. 2012 Jan 20;40(9):4237–4246. doi: 10.1093/nar/gkr1235

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — WDR5 binds MLL1-4, SET1A and SET1B Win motifs. ITC titration experiments with MLL1_Win (A), MLL2_Win (B), MLL3_Win (C), MLL4_Win (D), SET1A_Win (E) and SET1B_Win (F) peptides and WDR5 (upper trace) and the fitted binding curve (lower trace). The sequence of the Win motifs and the K_D are indicated as insets. Titration of WDR5 with Win peptides displays binding stoichiometries (N values) between 0.9 and 1.0.