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. 2007 Jan;14(1):46–52.

Table 1 :

Mahmood’s modified grading system for meningioma (6)

Score Brain invasion Mitosis Nuclear pleomorphism Necrosis* Hypercellularity Loss of architecture
0 Absent none Uniform, bland nuclei, no nucleoli none 10 whorls fascicles/ HPF none
1 Tumor pushing the brain without intervening meaning 1-1/10HPH Occasional larger nuclei, 2–3 times larger with irregular contours Rare, each involving less than 1/2 of HPF 10 whorls-fascicles/ HPF or increased cellularity in perivascular area Incipient loss
2 Cords infiltrating the brain 3–4/10HPF Many cells with large pale nuclei, small non prominent nucleoli Frequent foci involving more than 1/2 but less than 1 HPF Less defined, small, more closely packed whorls (up to 30/ HPF) Involving 1–2 HPF
3 >5/10HPF Most cells with nuclei, variable size, prominent nucleoli Large confluent areas of necrosis >1 HPF Densely crowded overlapping nuclei with loss of whorls Involving more than 2 adjacent HPF

Score 0–4 =benign, Score 5–11 =atypical, Score>11 =malignant

*

In the absence of preoperative tumor embolization and radiation therapy