Table 1 :
Score | Brain invasion | Mitosis | Nuclear pleomorphism | Necrosis* | Hypercellularity | Loss of architecture |
---|---|---|---|---|---|---|
0 | Absent | none | Uniform, bland nuclei, no nucleoli | none | 10 whorls fascicles/ HPF | none |
1 | Tumor pushing the brain without intervening meaning | 1-1/10HPH | Occasional larger nuclei, 2–3 times larger with irregular contours | Rare, each involving less than 1/2 of HPF | 10 whorls-fascicles/ HPF or increased cellularity in perivascular area | Incipient loss |
2 | Cords infiltrating the brain | 3–4/10HPF | Many cells with large pale nuclei, small non prominent nucleoli | Frequent foci involving more than 1/2 but less than 1 HPF | Less defined, small, more closely packed whorls (up to 30/ HPF) | Involving 1–2 HPF |
3 | >5/10HPF | Most cells with nuclei, variable size, prominent nucleoli | Large confluent areas of necrosis >1 HPF | Densely crowded overlapping nuclei with loss of whorls | Involving more than 2 adjacent HPF |
Score 0–4 =benign, Score 5–11 =atypical, Score>11 =malignant
In the absence of preoperative tumor embolization and radiation therapy