Figure 1.

Immunohistochemical analysis of UbcH10 protein in biopsy specimens of lung cancer. UbcH10-positive staining was brown, mostly located in the cell nucleus. (A) Well-differentiated adenocarcinoma (asterisk indicates transformed epithelium; arrows indicate UbcH10 stained cells). (B) Poorly differentiated adenocarcinoma (arrows indicate strongly labeled neoplastic elements). (C) Well-differentiated squamous cell carcinoma (asterisks indicate positively stained cells). (D) Poorly differentiated squamous cell carcinoma (arrows point to some of the positively stained areas). (E) Large cell lung carcinoma. (F) Small cell carcinoma. In the well-differentiated tumors (A–C), UbcH10 immune reaction was weaker than in poorly differentiated ones (B–D). Scale bars = 80 µm.