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Evolutionary history of corticosteroid receptors and structure of AncGR2-TIF2-MOF. A, simplified phylogenetic tree depicting the evolution of corticosteroid receptors. Activating hormones are listed on the right. ER, estrogen receptor; ERR, estrogen receptor-related receptor. B, structure of AncGR2 (red) in complex with human TIF2 (green) and MOF (cyan). C, AncGR2 LBP residues (red) with MOF shown (cyan).
