Table 2.
Clinical and parasitological data at baseline and end of study for cross sectional survey. Values are means (ranges) unless stated otherwise
| Baseline
|
End of study
|
||||
|---|---|---|---|---|---|
| Zinc group (n=332) | Placebo group (n=329) | Zinc group (n=334) | Placebo group (n=327) | ||
| Clinical characteristics | |||||
| Weight (kg) | 8.8 (4.9-15.0) | 8.6 (3.4-15.0) | 9.9 (5.9-16.1) | 9.6 (3.9-16.1) | |
| Height (cm) | 76.1 (62-94) | 75.4 (56-99) | 81.0 (65-97) | 80.2 (58-99) | |
| No (%) with enlarged spleen* | 272 (87) | 275 (87) | 300 (97) | 288 (98) | |
| No (%) with temperature ⩾37.5°C* | 27 (8.1) | 16 (4.9) | 30 (9.0) | 32 (9.8) | |
| No (%) with clinical malaria† | 4 (1.6) | 3 (1.2) | 18 (5.7) | 20 (6.7) | |
| Packed cell volume (%)‡ | 32.6 (26-44) | 31.7 (24-38) | 28.6 (18-38) | 29.7 (22-36) | |
| Parasitological characteristics | |||||
| No (%) with Plasmodium falciparum density: | |||||
| ⩾1/μl | 154 (60.1) | 169 (65.5) | 287 (90.3) | 264 (88.9) | |
| ⩾5000/μl | 20 (7.9) | 31 (12.0) | 128 (40.3) | 122 (41.1) | |
| ⩾100 000/μl | 0 (0) | 0 (0) | 1 (0.3) | 3 (1.0) | |
| Mean P falciparum density/μl | 2754 | 3090 | 7602 | 8333 | |
| No (%) with P malariae density ⩾1/μl | 10 (4.0) | 11 (4.3) | 46 (14.5) | 35 (11.8) | |
| Mean P malariae density/μl | 914 | 219 | 674 | 907 | |
| No (%) with P ovale density ⩾1/μl | 1 (0.4) | 2 (0.8) | 68 (21.4) | 57 (19.2) | |
| Mean P ovale density/μl | 16 | 345 | 348 | 498 | |
| Zinc measurement§ | |||||
| Serum zinc (mmol/l) | 11.5 (5.2-27.2) | 11.9 (5.6-20.5) | 15.3 (4.8-30.2) | 12.4 (5.0-27.4) | |
*
Individuals with missing data were excluded from denominator.
†
Temperature ⩾ 37.5°C, ⩾5000 parasites/μl.
‡
In paired subsample of 70 children (39 zinc, 31 placebo) at baseline and end of study.
§
In paired subsample of 81 children (41 zinc, 40 placebo) at baseline and mid-study.