TABLE 2.

Proportions of secondary structure induced by selected detergents

CD spectra were acquired using an Aviv model 62 DS CD spectrometer, buffer corrected, and the resulting spectra were analyzed using the SELCON and CDSSTR algorithms in the CDPro Suite of SVD tools. These algorithms provided the proportions of secondary structure that reconstituted the CD spectra observed in the presence of each compound (representative data in Fig. 6).

Sample	α	β	Turn	Random
	%	%	%	%
Aβ1–42 alone	7.8	22.4	20.6	49.2
+ Deoxycholatea	0.1	56.4	16.4	27.1
+Octyl Thioglucosidea	0	53.7	17.1	29.2
+ Fos-Choline 8a	3.8	47.4	21.1	27.7
+ Thesita	15.2	33.6	19.9	31.3
+ N-Decanoyl sucrosea	3.2	47.3	18.8	30.7
+ CYMAL 2a	16.3	26.5	20.1	37.1
+ C13E8b	58.1	5.4	20.1	16.4
+ LDAOb	65.2	6.3	16.4	12.1
+ Fos-Choline 10b	51.2	3.5	22.4	22.9
+ MEGA-8b	55.3	3.9	15.6	25.2
+ CycloFos-Choline 3b	54.2	4.7	19.1	32
+ CYMAL 3b	45.3	15.3	19.2	20.2

^a Indicates activating compounds.

^b Indicates inhibitory compounds.