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. 2012 Mar 23;287(20):16356–16364. doi: 10.1074/jbc.M111.325951

FIGURE 1.

FIGURE 1.

aPC treatment delays the onset and decreases the incidence of diabetes in NOD mice. A, glucose tolerance of nondiabetic NOD mice at 11 weeks of age (n = 6) after treatment with aPC (2 mg/kg) or PBS for 5 weeks from 6 to 10 weeks of age. Glucose was measured in blood from the tail vein at base line (0) and 30, 60, 90, 120, and 180 min after glucose administration. B, diabetes incidence in NOD mice treated with aPC (2 mg/kg) or PBS for 5 weeks from 6 to 10 weeks of age (n = 22). C, diabetes incidence in NOD mice treated with aPC (2 mg/kg) for 10 weeks from 6 to 15 weeks of age (aPC group: n = 13; PBS group, n = 10). D, blood glucose levels of mice treated with aPC or PBS after diabetes had developed (n = 8). Mice were treated with aPC twice a week for 5 weeks and received basal insulin daily. E, diabetic incidence in NOD mice treated with aPC or PC (2 mg/kg, six mice/group) for 5 weeks from 6 to 10 weeks of age. All results are expressed as mean ± S.E. For B, C, and E, p value represents statistical difference between the curves using Survival plots (Kaplan-Meier) and log rank analysis. *, p < 0.05.