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aPC increases/activates MMP-2 and decreases MMP-9 by islets or spleen cells of NOD mice. A, MMP-2 and -9 expression in islets from 26-week-old aPC- or PBS-treated nondiabetic NOD mice or BALB/c mice. Scale bar, 100 μm. B, MMP-2 and -9 in media of spleen cells from 10-week-old BALB/c or nondiabetic NOD mice in response to aPC treatment for 24 h, as detected by zymography. Images are representative of three independent experiments. *, p < 0.05; **, p < 0.01.
