FIGURE 2.

HDX-MS results for CDK2AP1. Back-exchange corrected deuteration (Deut) levels were estimated on a per residue basis and were derived from 36 overlapping peptide fragments and are shown according to the color coding indicated. Peptide fragments from the red regions exhibit essentially 100% amide proton exchange in the indicated time frame, whereas peptide fragments in the blue regions exhibit essentially no amide proton exchange in the corresponding time frame. Amide proton ¹H/²H exchange times (H-D) were 10 and 100 s. Secondary structural elements are shown below the protein sequence information.